炎症性肠病患者中的中性粒细胞趋化因子GCP-2和GRO-α

Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease.

作者信息

Alzoghaibi Mohammed A, Al-Mofleh Ibramim A, Al-Jebreen Abdulrhman M

机构信息

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

J Dig Dis. 2008 Aug;9(3):144-8. doi: 10.1111/j.1751-2980.2008.00336.x.

DOI:10.1111/j.1751-2980.2008.00336.x

PMID:18956592

Abstract

OBJECTIVE

To measure the serum levels of neutrophils chemokine granulocyte chemotactic protein-2 (GCP-2) and interleukin-8 (IL-8) in Crohn's disease (CD) and ulcerative colitis (UC) patients and compare them with serum levels of growth-related oncogene (GRO-alpha).

METHODS

Forty-two patients with inflammatory bowel disease (24 CD and 18 UC) and 38 matched healthy subjects were recruited. Their serum GCP-2, IL-8 and GRO-alpha were measured by a specific enzyme immunoassay kit.

RESULTS

The serum levels of GCP-2 were significantly higher in the CD than the UC patients but lower than in the healthy subjects. The GCP-2 in the UC patients were significantly lower than in the healthy subjects. The GRO-alpha levels were significantly higher in the IBD patients than in the healthy subjects. The IL-8 levels were under the detectable limit in both the IBD and the healthy subjects.

CONCLUSION

In this group of patients, GCP-2 did not participate in the inflammatory response in IBD. GRO-alpha could be an important factor that enhances the inflammatory state in IBD.

摘要