烯丙基二苯基甘氨酸酯亚胺的一锅串联脱羧烯丙基化-赫克环化反应：快速合成多官能化1-氨基茚满

One-pot tandem decarboxylative allylation-Heck cyclization of allyl diphenylglycinate imines: rapid access to polyfunctionalized 1-aminoindanes.

作者信息

Fields Wendy H, Khan Ali K, Sabat Michal, Chruma Jason J

机构信息

Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.

出版信息

Org Lett. 2008 Nov 20;10(22):5131-4. doi: 10.1021/ol801986m. Epub 2008 Oct 29.

DOI:10.1021/ol801986m

PMID:18956870

Abstract

1-Aminoindanes are generated from allyl diphenylglycinate imines employing a "one-pot" palladium-catalyzed decarboxylative allylation-Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products and other biologically relevant small molecules.

摘要

通过“一锅法”钯催化脱羧烯丙基化-赫克环化串联反应，从烯丙基二苯基甘氨酸亚胺生成1-氨基茚满。芳基和烯丙基部分的变化导致了多种多环亚胺的产生，适用于天然产物和其他具有生物相关性的小分子的合成。