Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
Org Lett. 2010 Jan 15;12(2):316-9. doi: 10.1021/ol902651j.
General reaction conditions for the Pd-catalyzed decarboxylative benzylation of benzyl diphenylglycinate imines are described. The overall procedure requires a simple catalyst/ligand combination to form a new Csp(3)-Csp(3) bond. Microwave irradiation greatly accelerated the transformation. Moreover, various heteroaromatic moieties are tolerated in both the imine and ester components.
描述了 Pd 催化的苯甲酰基二苯甘氨酸亚胺的脱羧苄基化的一般反应条件。整个过程需要简单的催化剂/配体组合来形成新的 Csp(3)-Csp(3)键。微波辐射大大加速了转化。此外，在亚胺和酯部分都可以容忍各种杂芳族部分。
