Siamaki Ali R, Black Daniel A, Arndtsen Bruce A
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, H3A 2K6, Canada.
J Org Chem. 2008 Feb 1;73(3):1135-8. doi: 10.1021/jo701875b. Epub 2007 Dec 29.
The palladium-catalyzed coupling of imines, chloroformates, organotin reagents, and carbon monoxide leads to the one-pot formation of ketocarbamates in good yields. These products can further be converted to highly substituted imidazolones via a cyclocondensation reaction. Overall, this methodology provides an alternative approach to imidazolones from five simple and readily available building blocks via a one-pot, multicomponent process.
钯催化的亚胺、氯甲酸酯、有机锡试剂和一氧化碳的偶联反应能够一锅法高产率地生成酮基氨基甲酸酯。这些产物可通过环缩合反应进一步转化为高度取代的咪唑酮。总体而言，该方法通过一锅多组分过程，从五个简单易得的原料出发，为合成咪唑酮提供了一种替代方法。
