Miller Jena L, Harman Christopher, Weiner Carl, Baschat Ahmet A
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland Medical Center, Baltimore, MD 21201, USA.
J Perinat Med. 2009;37(2):140-3. doi: 10.1515/JPM.2009.027.
Symptomatic fetal viral infection can affect placental and fetal development and may lead to non-immune hydrops or fetal death. All infections are not detectable by clinical history or ultrasound and a background positivity rate exists in asymptomatic patients. We investigated if intraamniotic presence of viral genome at the time of genetic amniocentesis in asypmtomatic patients affects perinatal outcome.
Six-hundred and eighty-six pregnancies referred for second trimester genetic amniocentesis with a normal ultrasound and fetal karyotype had amniotic fluid multiplex polymerase chain reaction for adeno-, cytomegalo-, Ebstein-Barr-, entero- and parvovirus. Forty asymptomatic patients that were positive for viral genome were matched 2:1 with negative controls. Perinatal outcomes were compared between these groups.
Pregnancy complications and perinatal outcomes were similar in the two groups.
Asymptomatic fetal viral infection at the time of second trimester amniocentesis does not increase the risk for adverse perinatal outcome.
有症状的胎儿病毒感染可影响胎盘和胎儿发育，并可能导致非免疫性水肿或胎儿死亡。并非所有感染都可通过临床病史或超声检测出来，无症状患者存在背景阳性率。我们研究了无症状患者在遗传羊膜穿刺术时羊膜腔内病毒基因组的存在是否会影响围产期结局。
686例因孕中期遗传羊膜穿刺术前来就诊、超声检查和胎儿核型正常的孕妇，其羊水进行了腺病毒、巨细胞病毒、EB病毒、肠道病毒和细小病毒的多重聚合酶链反应检测。40例病毒基因组呈阳性的无症状患者与阴性对照按2:1进行匹配。比较了这些组之间的围产期结局。
两组的妊娠并发症和围产期结局相似。
孕中期羊膜穿刺术时无症状的胎儿病毒感染不会增加不良围产期结局的风险。
