Prosper F
Servicio de Hematología y Area de Terapia Celular Clínica Universitaria Av. Pío XII, 3631008 Pamplona.
Nefrologia. 2008;28 Suppl 6:71-9.
The derivation of the first human embryonic stem cell lines as well as the notion of the unexpected plasticity and potential of the adult stem cells has significantly impacted the biomedical research. Many of the tissues long believe to lack any regenerative capacity has demonstrated otherwise. Patients alike physicians expectations for treatment of incurable diseases have also fuelled this field and in occasions have led to unrealistic expectations. In the next pages I review some of the tissue specific stem cells that have been used either in preclinical models or even in clinical research. Despite the effort of numerous investigators, more questions that answers remain in the field of cell therapy and only careful and independent -not biased- research will allow us to translate some of this findings into clinical application.
首批人类胚胎干细胞系的衍生以及成体干细胞出人意料的可塑性和潜能概念，对生物医学研究产生了重大影响。许多长期以来被认为缺乏任何再生能力的组织，事实却并非如此。患者和医生对治疗不治之症的期望也推动了该领域的发展，有时甚至导致了不切实际的期望。在接下来的几页中，我将回顾一些已在临床前模型甚至临床研究中使用的组织特异性干细胞。尽管众多研究人员付出了努力，但细胞治疗领域仍存在更多问题而非答案，只有谨慎且独立（无偏见）的研究才能使我们将其中一些发现转化为临床应用。
