束缚我，压制我：抑制RNA聚合酶
Tie me up, tie me down: inhibiting RNA polymerase.
作者信息
Sousa Rui
机构信息
Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
出版信息
Cell. 2008 Oct 17;135(2):205-7. doi: 10.1016/j.cell.2008.09.052.
Abstract
Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.
摘要
对抗生素作用机制的深入理解能够产生关键见解，有助于新型抗生素的设计。在本期中，穆克霍帕德亚等人（2008年）揭示了抗生素黏菌素抑制细菌RNA聚合酶的机制，为抑制剂设计指出了RNA聚合酶中的一个新靶点区域。
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The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.RNA聚合酶II触发环在底物选择中发挥作用，并直接受到α-鹅膏蕈碱的靶向作用。
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Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.链霉溶菌素对细菌RNA聚合酶的抑制作用：直桥螺旋活性中心构象的稳定化
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