新型粘霉素B类似物作为细菌RNA聚合酶潜在抑制剂的合成。
Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.
作者信息
Lira Ricardo, Xiang Alan X, Doundoulakis Thomas, Biller William T, Agrios Konstantinos A, Simonsen Klaus B, Webber Stephen E, Sisson Wes, Aust Robert M, Shah Amit M, Showalter Richard E, Banh Virginia N, Steffy Kevin R, Appleman James R
机构信息
Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, CA 92121, USA.
出版信息
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6797-800. doi: 10.1016/j.bmcl.2007.10.017. Epub 2007 Oct 17.
Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus.
基于我们初步研究结果的观察，已制备了额外的黏菌素B类似物，并测试了其对依赖DNA的RNA聚合酶的体外抑制活性以及对大肠杆菌和金黄色葡萄球菌的抗菌活性。
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