Smach M A, Charfeddine B, Lammouchi T, Dridi H, Ben Othman L, Bennamou S, Limem K
Département de biochimie, Faculté de médecine de Sousse, Tunisie.
Ann Biol Clin (Paris). 2008 Sep-Oct;66(5):531-5. doi: 10.1684/abc.2008.0265.
Early diagnosis of Alzheimer's disease remains a tactful poser. In order to clarify the importance of beta amyloid protein dosage (Abeta1-42) and protein tau (t-tau) in such pathology, we have rigorously studied three well recruited populations that match in age: healthy controls (n = 32), Alzheimer patients (n = 87) and non Alzheimer dementia (n = 31) patients. The combination of Abeta1-42 and t-tau at baseline yielded a sensitivity of 85.29 % for detection of Alzheimer's disease and the specificity was by 96.77 % to differentiate controls. So the combination of these tow markers helps in the diagnosis of Alzheimer because of the high specificity and sensibility of this method.
阿尔茨海默病的早期诊断仍然是一个棘手的问题。为了阐明β淀粉样蛋白剂量（Abeta1-42）和tau蛋白（t-tau）在这种病理中的重要性，我们对三个精心招募的年龄匹配人群进行了严格研究：健康对照组（n = 32）、阿尔茨海默病患者（n = 87）和非阿尔茨海默病痴呆患者（n = 31）。基线时Abeta1-42和t-tau的联合检测对阿尔茨海默病的检测灵敏度为85.29%，区分对照组的特异性为96.77%。因此，由于该方法具有高特异性和敏感性，这两种标志物的联合有助于阿尔茨海默病的诊断。
