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Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease.

作者信息

Yankner Bruce A, Lu Tao

机构信息

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

J Biol Chem. 2009 Feb 20;284(8):4755-9. doi: 10.1074/jbc.R800018200. Epub 2008 Oct 28.

DOI:10.1074/jbc.R800018200
PMID:18957434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2643502/
Abstract
摘要

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本文引用的文献

1
Relevance of transgenic mouse models to human Alzheimer disease.转基因小鼠模型与人类阿尔茨海默病的相关性。
J Biol Chem. 2009 Mar 6;284(10):6033-7. doi: 10.1074/jbc.R800030200. Epub 2008 Oct 22.
2
Amyloid beta-protein assembly and Alzheimer disease.淀粉样β蛋白组装与阿尔茨海默病。
J Biol Chem. 2009 Feb 20;284(8):4749-53. doi: 10.1074/jbc.R800036200. Epub 2008 Oct 9.
3
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.阿尔茨海默病小鼠模型中β-淀粉样蛋白斑块的快速出现及局部毒性
Nature. 2008 Feb 7;451(7179):720-4. doi: 10.1038/nature06616.
4
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.淀粉样前体蛋白通过激活Go蛋白介导β淀粉样蛋白的神经元毒性。
Neurobiol Aging. 2009 Sep;30(9):1379-92. doi: 10.1016/j.neurobiolaging.2007.11.017. Epub 2008 Jan 10.
5
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.阿尔茨海默病β-淀粉样蛋白神经毒性淀粉样纤维中间态中纤维状β-折叠结构的证据。
Nat Struct Mol Biol. 2007 Dec;14(12):1157-64. doi: 10.1038/nsmb1345.
6
The aging brain.衰老的大脑。
Annu Rev Pathol. 2008;3:41-66. doi: 10.1146/annurev.pathmechdis.2.010506.092044.
7
Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.轻度认知障碍中的皮质失活：高场强功能磁共振成像
Radiology. 2007 Oct;245(1):224-35. doi: 10.1148/radiol.2451061847.
8
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.阿尔茨海默病小鼠模型中异常的兴奋性神经元活动及海马抑制性回路的代偿性重塑
Neuron. 2007 Sep 6;55(5):697-711. doi: 10.1016/j.neuron.2007.07.025.
9
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.加速淀粉样β蛋白纤维化可降低阿尔茨海默病小鼠模型中的寡聚体水平和功能缺陷。
J Biol Chem. 2007 Aug 17;282(33):23818-28. doi: 10.1074/jbc.M701078200. Epub 2007 Jun 4.
10
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.在阿尔茨海默病小鼠模型中，减少内源性tau可改善β淀粉样蛋白诱导的缺陷。
Science. 2007 May 4;316(5825):750-4. doi: 10.1126/science.1141736.