先天性心脏病患儿的凝血酶生成。通过校准自动血栓形成测定法进行测定。

Thrombin generation in paediatric patients with congenital heart disease. Determination by calibrated automated thrombography.

作者信息

Koestenberger M, Cvirn G, Rosenkranz A, Leschnik B, Raith W, Muntean W

机构信息

Department of Paediatrics, Medical University Graz, Auenbruggerplatz 30, 8036 Graz, Austria.

出版信息

Hamostaseologie. 2008 Oct;28 Suppl 1:S61-6.

PMID:18958342

Abstract

UNLABELLED

Thrombin generation was studied in paediatric patients with congenital heart disease (CHD) undergoing cardiac surgery using the calibrated automated thrombography (CAT) in terms of the lag time until the onset of thrombin formation, time to thrombin peak maximum (TTP), endogenous thrombin potential (ETP), and thrombin peak height. The suitability to determine the coagulation status of these patients was investigated.

PATIENTS, MATERIAL, METHODS: CAT data of 40 patients with CHD (age range from newborn to 18 years) were compared to data using standard coagulation parameters such as prothrombin (FII), antithrombin (AT), tissue factor pathway inhibitor (TFPI), prothrombin fragment 1.2 (F 1.2), thrombin-antithrombin (TAT), activated partial thromboplastin time (aPTT), and prothrombin time (PT).

RESULTS

A significant positive correlation was seen between ETP and FII (p < 0.01; r = 0.369), as well as between peak height and FII (p < 0.01; r = 0.483). A significant negative correlation was seen between ETP and TFPI values (p < 0.05; r = -0.225) while no significant correlation was seen between peak height and TFPI. A significant negative correlation was seen between F 1.2 generation and ETP (p < 0.05; r = -0.254) and between F 1.2 generation and peak height (p < 0.05; r = -0.236). No correlation was seen between AT and ETP or peak.

CONCLUSIONS

CAT is a good global test reflecting procoagulatory and inhibitory factors of the haemostatic system in paediatric patients with CHD.

摘要

未标注

采用校准自动血栓形成描记法（CAT），研究了接受心脏手术的先天性心脏病（CHD）患儿的凝血酶生成情况，涉及凝血酶形成开始前的延迟时间、凝血酶峰值最大时间（TTP）、内源性凝血酶潜力（ETP）和凝血酶峰值高度。研究了CAT用于确定这些患者凝血状态的适用性。

患者、材料、方法：将40例CHD患者（年龄范围从新生儿到18岁）的CAT数据与使用标准凝血参数的数据进行比较，这些标准凝血参数包括凝血酶原（FII）、抗凝血酶（AT）、组织因子途径抑制剂（TFPI）、凝血酶原片段1.2（F 1.2）、凝血酶 - 抗凝血酶（TAT）、活化部分凝血活酶时间（aPTT）和凝血酶原时间（PT）。

结果

ETP与FII之间存在显著正相关（p < 0.01；r = 0.369），峰值高度与FII之间也存在显著正相关（p < 0.01；r = 0.483）。ETP与TFPI值之间存在显著负相关（p < 0.05；r = -0.225），而峰值高度与TFPI之间未发现显著相关性。F 1.2生成与ETP之间存在显著负相关（p < 0.05；r = -0.254），F 1.2生成与峰值高度之间也存在显著负相关（p < 0.05；r = -0.236）。AT与ETP或峰值之间未发现相关性。