Oh Hwa Eun, Chetty Runjan
Department of Pathology, University Health Network/Toronto Medical Laboratories, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.
J Gastroenterol. 2008;43(10):741-50. doi: 10.1007/s00535-008-2230-5. Epub 2008 Oct 29.
Eosinophilic gastroenteritis is a clinicopathological disease affecting both children and adults that is characterized by patchy or diffuse eosinophilic infiltration of the gastrointestinal tract with variable resultant clinical gastrointestinal manifestations. The eosinophil, eotaxin, and Th-2 cytokines are important in pathogenesis of this disease entity. It may be confused with parasitic and bacterial infections (including Helicobacter pylori), inflammatory bowel disease, hypereosinophilic syndrome, myeloproliferative disorders, periarteritis, allergic vasculitis, scleroderma, drug injury, and drug hypersensivity. Obtaining the correct diagnosis is important, and a pathologist usually makes this distinction. Effective treatments include systemic/topical corticosteroids, specific food elimination or an elemental diet, certain drugs, and even surgery. A variety of new therapeutic approaches are now under trial.
嗜酸性胃肠炎是一种影响儿童和成人的临床病理疾病，其特征是胃肠道出现斑片状或弥漫性嗜酸性粒细胞浸润，并伴有各种不同的临床胃肠道表现。嗜酸性粒细胞、嗜酸性粒细胞趋化因子和Th-2细胞因子在该疾病实体的发病机制中起重要作用。它可能与寄生虫和细菌感染（包括幽门螺杆菌）、炎症性肠病、高嗜酸性粒细胞综合征、骨髓增殖性疾病、动脉周围炎、过敏性血管炎、硬皮病、药物损伤和药物过敏相混淆。获得正确的诊断很重要，通常由病理学家进行鉴别。有效的治疗方法包括全身/局部使用皮质类固醇、特定食物排除或要素饮食、某些药物，甚至手术。目前正在试验各种新的治疗方法。
