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会议报告:免疫介导药物超敏反应(IDHR)研讨会。

Meeting Report Immune-Mediated Drug Hypersensitivity Reactions (IDHR) Workshop.

机构信息

Safety Sciences, Pfizer Global Research and Development, Groton, Connecticut, USA.

出版信息

J Immunotoxicol. 2005 Jul 1;1(3):201-5. doi: 10.1080/15476910490898135.

Abstract

Immune-mediated drug hypersensitivity reactions (IDHR) are relatively rare reactions to drugs that can be observed in a limited population of patients, yet these reactions can have significant impacts on public health, clinical practice, and drug development. Despite the potentially significant impact of IDHR, research into the causes and mechanisms of action of these reactions has been limited. In order to identify and enhance potential research opportunities in IDHR, the Health and Environmental Sciences Institute (HESI) hosted a two-day workshop involving stakeholders from government, academia, and industry. Discussions focused on ways to increase IDHR research opportunities within both presently existing collaborative structures and new networks. Based on these discussions, workshop participants concluded that a volunteer organization of interested stakeholders could be established to provide for ongoing advocacy and coordination of efforts related to IDHR research. The primary objectives of such an organization would be to increase public awareness of the impact of IDHR, encourage multidisciplinary IDHR research and training, encourage the development and funding of IDHR research network and seed grants, and to establish a framework for the further exchange and dissemination of IDHR information.

摘要

免疫介导的药物超敏反应(IDHR)是一种相对罕见的药物反应,仅在有限的患者群体中观察到,但这些反应会对公共卫生、临床实践和药物开发产生重大影响。尽管 IDHR 可能会产生重大影响,但对这些反应的原因和作用机制的研究却很有限。为了确定和加强 IDHR 的潜在研究机会,健康与环境科学协会(HESI)举办了为期两天的研讨会,邀请了来自政府、学术界和工业界的利益相关者参加。讨论的重点是如何在现有的合作结构和新网络中增加 IDHR 研究机会。基于这些讨论,研讨会参与者得出结论,一个由利益相关者组成的志愿者组织可以成立,以提供持续的倡导和协调与 IDHR 研究相关的工作。该组织的主要目标将是提高公众对 IDHR 影响的认识,鼓励多学科 IDHR 研究和培训,鼓励 IDHR 研究网络和种子基金的发展和资助,并为进一步交流和传播 IDHR 信息建立框架。

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