Schneider Frank, Sporn Thomas A, Roggli Victor L
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Ultrastruct Pathol. 2008 Sep-Oct;32(5):171-7. doi: 10.1080/01913120802343848.
This study reports changes in the frequency of detection of various asbestos fiber types between 1982 and 2005. Crocidolite is increasingly detected in U.S. mesothelioma patients. The percentage of crocidolite fibers detected in lung tissue has risen from 4 to 10%, and the percentage of cases in which crocidolite was detected increased from 19 to 37%. Meanwhile, the frequency of detection of amosite and chrysotile has decreased. The authors performed a detailed analysis of cases in which crocidolite was identified in the absence of amosite. Most of such cases were identified in recent years, a finding of concern since crocidolite is considered the most potent fiber type with respect to the pathogenesis of mesothelioma.
本研究报告了1982年至2005年间各种石棉纤维类型检测频率的变化。在美国间皮瘤患者中，青石棉的检测越来越多。在肺组织中检测到的青石棉纤维百分比已从4%上升至10%，检测到青石棉的病例百分比从19%增加到37%。与此同时，铁石棉和温石棉的检测频率有所下降。作者对在没有铁石棉的情况下鉴定出青石棉的病例进行了详细分析。大多数此类病例是近年来发现的，这一发现令人担忧，因为就间皮瘤的发病机制而言，青石棉被认为是最具毒性的纤维类型。
