Metugriachuk Yussef, Marotta Francesco, Kuroi Ojime, Tsuchiya Junji, Goh Khean-Lee, Minelli Emilio, Kawakita Satoru
TMC Hospital, Shizuoka, Japan.
J Dig Dis. 2008 Nov;9(4):204-7. doi: 10.1111/j.1751-2980.2008.00347.x.
The aim of the present study was to assess the efficacy of a hydro-alcoholic solution of a phytocompound based on Gentianae, Cinchonae, Absinthii and Cinnamomi on gastric emptying in Helicobacter pylori-negative dyspeptic patients.
The study group consisted of 24 patients with a diagnosis of long-standing dismotility-like functional dyspepsia. All patients were devoid of any major past or ongoing disease and dyspepsia-associated diseases were excluded. After a 2-week wash out period, the patients were randomized to a 2-week treatment in which they were given 20 gtt of the compound 30 min before meals. At the beginning and end of the study, a gastric emptying test was performed by a paracetamol absorption test using a standard meal. The global symptom index (GSI) was assessed daily by a validated questionnaire.
Treatment with the phytocompound significantly improved the gastric emptying test (P < 0.01) which was delayed in dyspeptic patients as well as GSI (P < 0.05).
This phytocompound might be an effective therapeutic option in the treatment of dismotility-like dyspepsia.
