慢性肾衰竭患者的消化不良与胃排空

Dyspepsia and gastric emptying in chronic renal failure patients.

作者信息

Van Vlem B, Schoonjans R, Vanholder R, Vandamme W, De Vos M, Lameire N

机构信息

Department of Internal Medicine, Ghent University Hospital, Belgium.

出版信息

Clin Nephrol. 2001 Oct;56(4):302-7.

PMID:11680660

Abstract

AIMS

Chronic renal failure (CRF) patients frequently suffer from dyspeptic complaints such as nausea, vomiting, abdominal distension, early satiety and anorexia. The aim of the present study was to define the prevalence of dyspeptic complaints and delayed gastric emptying in CRF patients.

MATERIAL AND METHODS

Dyspeptic complaints were assessed anamnestically in 62 non-dialyzed CRF patients. Gastric emptying for solids was evaluated by the 13C-octanoic acid breath test in the same population. The CRF patients were compared to 27 healthy volunteers.

RESULTS

There was a high prevalence (48%) of dysmotility-like dyspepsia in the investigated population. The gastric emptying rates of CRF patients and healthy volunteers were significantly different (median gastric emptying t(1/2) 83 min versus 60 min, p < 0.01). Diabetic CRF patients had lower gastric emptying rates than non-diabetic CRF patients (median gastric emptying time t(1/2) 113 min versus 77 min, p < 0.01). Even the non-diabetic CRF patients had a significantly delayed gastric emptying rate compared to the healthy volunteers (77 min versus 60 min, p < 0.05).

CONCLUSION

It is concluded that dysmotility-like dyspeptic complaints and delayed gastric emptying are highly prevalent in CRF patients.

摘要

目的

慢性肾衰竭（CRF）患者经常出现消化不良症状，如恶心、呕吐、腹胀、早饱感和厌食。本研究的目的是确定CRF患者消化不良症状和胃排空延迟的患病率。

材料与方法

对62例未接受透析的CRF患者进行问诊，评估其消化不良症状。在同一人群中，通过13C-辛酸呼气试验评估固体食物的胃排空情况。将CRF患者与27名健康志愿者进行比较。

结果

在被调查人群中，运动障碍样消化不良的患病率很高（48%）。CRF患者和健康志愿者的胃排空率有显著差异（胃排空中位t(1/2) 83分钟对60分钟，p < 0.01）。糖尿病CRF患者的胃排空率低于非糖尿病CRF患者（胃排空中位时间t(1/2) 113分钟对77分钟，p < 0.01）。即使是非糖尿病CRF患者，与健康志愿者相比，胃排空率也显著延迟（77分钟对60分钟，p < 0.05）。