Tague L L, Samir Amer M, Jacobson E D
Am J Dig Dis. 1977 Jan;22(1):13-5. doi: 10.1007/BF01077391.
Canine gastric mucosal cyclic AMP content was determined at 1, 5, 30, 60, and 120 min after commencing a 2-hr continuous intravenous infusion of histamine of sufficient dose to elicit a brisk acid secretory response from the dog stomach. The increase in acid output was significant at 30 min and stabilized at the stimulated level for the duration of histamine infusion. By contrast, there was no significant increase in mucosal cyclic AMP content at any time of measurement. Our findings indicate that the acid secretory response of the canine stomach to histamine does not require prior accumulation of cyclic AMP in the mucosal tissue.
在对犬进行为期2小时的组胺持续静脉输注后，分别于1、5、30、60和120分钟测定犬胃黏膜环磷酸腺苷（cAMP）含量，输注组胺的剂量足以引起犬胃强烈的酸分泌反应。酸分泌量在30分钟时显著增加，并在组胺输注期间稳定在刺激水平。相比之下，在任何测量时间，黏膜cAMP含量均无显著增加。我们的研究结果表明，犬胃对组胺的酸分泌反应并不需要黏膜组织预先积累环磷酸腺苷。
