Querfeld U, Baisch C, Soergel M, Wingen A M, Waldherr R, Schärer K
Sektion für pädiatrische Nephrologie, Universität Heidelberg.
Monatsschr Kinderheilkd. 1991 Jun;139(6):336-41.
During the last two years we have observed three children, aged 12-15 years, who developed acute non-oliguric renal failure with concomitant uveitis. Acute interstitial nephritis with lympho-monocytic infiltrates was diagnosed in all cases by renal biopsy. While two patients went into spontaneous remission, renal function in the remaining child improved only after treatment with oral prednisone. Withdrawal of steroid medication was promptly followed by a relapse, necessitating steroid therapy for a total of 4 months. The clinical and histological findings were consonant with the so-called TINU syndrome. While the pathogenesis of this syndrome is unclear, the prognosis seems to be favorable and most cases resolve spontaneously. However, in some cases, prolonged therapy with corticosteroids may be required.
在过去两年中，我们观察到3名年龄在12至15岁的儿童，他们出现了急性非少尿性肾衰竭并伴有葡萄膜炎。所有病例经肾活检均诊断为伴有淋巴细胞浸润的急性间质性肾炎。两名患者自发缓解，而另一名儿童仅在口服泼尼松治疗后肾功能才有所改善。停用类固醇药物后病情迅速复发，因此总共需要4个月的类固醇治疗。临床和组织学表现与所谓的TINU综合征相符。虽然该综合征的发病机制尚不清楚，但其预后似乎良好，大多数病例可自发缓解。然而，在某些情况下，可能需要长期使用皮质类固醇进行治疗。
