Eber E, Varga E M, Zach M S
Department of Pediatrics, University of Graz, Austria.
Pediatr Pulmonol. 1991;10(4):273-7. doi: 10.1002/ppul.1950100409.
For pharmacological challenges, a correlation between the induced changes of the transcutaneously measured oxygen tension (PtcO2) and of conventional pulmonary function tests (PFTs) has been documented. We performed a 4-minute cold air challenge (CACh) in 17 children with bronchial asthma under continuous monitoring of PtcO2, and correlated observed changes with CACh-induced alterations of conventional PFTs. PtcO2 decreased significantly with CACh (from 86 +/- 10 mmHg to 66 +/- 14 mmHg, P less than 0.001), but returned to near-baseline within the next 30 minutes. PFTs changed with a similar pattern; the closest correlation was found between the CACh-induced fall of PtcO2 and Delta-FEV1 (r = 0.833, P less than 0.001). Changes of FVC, PEF, and Vmax50 correlated significantly as well. PtcO2 can complement or substitute for conventional PFTs in assessing the response to CACh in children.
对于药物激发试验，经皮测量的氧分压（PtcO2）的诱导变化与传统肺功能测试（PFTs）之间的相关性已有文献记载。我们对17名支气管哮喘儿童进行了4分钟的冷空气激发试验（CACh），同时持续监测PtcO2，并将观察到的变化与CACh诱导的传统PFTs改变进行关联。CACh时PtcO2显著下降（从86±10 mmHg降至66±14 mmHg，P<0.001），但在接下来的30分钟内恢复至接近基线水平。PFTs呈现类似的变化模式；CACh诱导的PtcO2下降与Δ-FEV1之间的相关性最为密切（r = 0.833，P<0.001）。FVC、PEF和Vmax50的变化也具有显著相关性。在评估儿童对CACh的反应时，PtcO2可以补充或替代传统PFTs。
