儿童气道反应性的冷空气激发试验：经皮测量的氧分压与传统肺功能的相关性

Cold air challenge of airway reactivity in children: a correlation of transcutaneously measured oxygen tension and conventional lung functions.

作者信息

Eber E, Varga E M, Zach M S

机构信息

Department of Pediatrics, University of Graz, Austria.

出版信息

Pediatr Pulmonol. 1991;10(4):273-7. doi: 10.1002/ppul.1950100409.

DOI:10.1002/ppul.1950100409

PMID:1896236

Abstract

For pharmacological challenges, a correlation between the induced changes of the transcutaneously measured oxygen tension (PtcO2) and of conventional pulmonary function tests (PFTs) has been documented. We performed a 4-minute cold air challenge (CACh) in 17 children with bronchial asthma under continuous monitoring of PtcO2, and correlated observed changes with CACh-induced alterations of conventional PFTs. PtcO2 decreased significantly with CACh (from 86 +/- 10 mmHg to 66 +/- 14 mmHg, P less than 0.001), but returned to near-baseline within the next 30 minutes. PFTs changed with a similar pattern; the closest correlation was found between the CACh-induced fall of PtcO2 and Delta-FEV1 (r = 0.833, P less than 0.001). Changes of FVC, PEF, and Vmax50 correlated significantly as well. PtcO2 can complement or substitute for conventional PFTs in assessing the response to CACh in children.

摘要

对于药物激发试验，经皮测量的氧分压（PtcO2）的诱导变化与传统肺功能测试（PFTs）之间的相关性已有文献记载。我们对17名支气管哮喘儿童进行了4分钟的冷空气激发试验（CACh），同时持续监测PtcO2，并将观察到的变化与CACh诱导的传统PFTs改变进行关联。CACh时PtcO2显著下降（从86±10 mmHg降至66±14 mmHg，P<0.001），但在接下来的30分钟内恢复至接近基线水平。PFTs呈现类似的变化模式；CACh诱导的PtcO2下降与Δ-FEV1之间的相关性最为密切（r = 0.833，P<0.001）。FVC、PEF和Vmax50的变化也具有显著相关性。在评估儿童对CACh的反应时，PtcO2可以补充或替代传统PFTs。