[一项使用Astograph和经皮氧分压对哮喘儿童支气管敏感性和支气管反应性的研究。同步测量的问题]

[A study of bronchial sensitivity and bronchial reactivity using Astograph and transcutaneous oxygen tension in asthmatic children. The problems of simultaneous measurement].

作者信息

Ichinose H, Mezawa K, Miyamoto M, Wakabayashi T

出版信息

Nihon Ika Daigaku Zasshi. 1989 Oct;56(5):488-93. doi: 10.1272/jnms1923.56.488.

DOI:10.1272/jnms1923.56.488

Abstract

Bronchial sensitivity and reactivity in 60 patients with bronchial asthma was measured using the Astograph and simultaneous transcutaneous oxygen tension [PtcO2]. In spite of increasing respiratory resistance, there were some cases in which PtcO2 did not show remarkable decrease. The PtcO2 percentage was defined as (basal value of PtcO2 - bottom value of PtcO2)/(basal value of PtcO2). The correlation between PtcO2% and the basal value of PtcO2 was relatively high (r = 0.42, n = 58, p less than 0.005). The correlation between PtcO2% and V50/Ht or V25/Ht was also relatively high (r = 0.41, n = 45, p less than 0.01, r = 0.49, n = 45, p less than 0.001, respectively). In some cases of small airway obstruction or low basal value of PtcO2, was smaller. The patients of over 70% in FEV1.0/VCP were in accord with that of over 70 mmHg in the basal value of PtcO2. The results suggest the recommended basal value of PtcO2 to measure bronchial sensitivity and reactivity may be over 70 mmHg.

摘要

使用Astograph和同步经皮氧分压[PtcO2]测量了60例支气管哮喘患者的支气管敏感性和反应性。尽管呼吸阻力增加，但仍有一些病例中PtcO2没有显著下降。PtcO2百分比定义为（PtcO2基础值 - PtcO2最低值）/（PtcO2基础值）。PtcO2%与PtcO2基础值之间的相关性相对较高（r = 0.42，n = 58，p < 0.005）。PtcO2%与V50/Ht或V25/Ht之间的相关性也相对较高（分别为r = 0.41，n = 45，p < 0.01；r = 0.49，n = 45，p < 0.001）。在一些小气道阻塞或PtcO2基础值较低的病例中，该值较小。FEV1.0/VCP超过70%的患者与PtcO2基础值超过70 mmHg的患者一致。结果表明，测量支气管敏感性和反应性时推荐的PtcO2基础值可能超过70 mmHg。