Wahbi A A, Belal S, Abdine H, Bedair M
Faculty of Pharmacy, University of Alexandria, Pharmaceutical Analytical Chemistry Department, Alexandra, Egypt.
Talanta. 1982 Nov;29(11 Pt 1):931-5. doi: 10.1016/0039-9140(82)80154-9.
A direct spectrophotometric method for the determination of methylphenobarbitone in presence of degradation products is presented. The method is based on use of the combined polynomial method. The coefficient of the combined polynomial P(w), calculated over the wavelength range 228-272 nm at 4-nm intervals, is unaffected by the presence of any degradation products and is linearly related to the methylphenobarbitone concentration with a relative standard deviation of 0.4%. The mean recovery is 99.1 +/- 0.8%. The method can also be used for assessing the stability of methylphenobarbitone.
本文提出了一种在有降解产物存在的情况下测定甲基苯巴比妥的直接分光光度法。该方法基于联合多项式法。在228 - 272 nm波长范围内以4 nm间隔计算得到的联合多项式P(w)的系数不受任何降解产物存在的影响，并且与甲基苯巴比妥浓度呈线性相关，相对标准偏差为0.4%。平均回收率为99.1±0.8%。该方法还可用于评估甲基苯巴比妥的稳定性。
