Lejeune J M, Charachon R
C.H.R.U. Grenoble, Clinique O.R.L., Grenoble, France.
Rev Laryngol Otol Rhinol (Bord). 1991;112(2):127-31.
We have looked for abnormal immunobiologic test in 12 cases of Meniere's disease and 11 cases of rapidly progressive sensorineural hearing loss. After ruling out known etiologies, they were screened with non specific tests (sedimentation rate, electrophoresis, immunoglobulins, circulating immune complexes, cryoglobulins, complement system, auto antibodies) and inner ear specific tests (antibodies against human cochlea by indirect immunofluorescent test and lymphocyte transformation test against a pool of human inner ear. A non specific inflammatory syndrome was found in more than 50% of cases, specific tests of the inner ear were positive in 30% of cases. Corticosteroid therapy achieved a significant improvement of the hearing in 100% of the patients with a positive specific test, versus 50% of those with a negative result. A therapeutic protocol is suggested taking into account the results of the immunobiologic tests.
我们对12例梅尼埃病患者和11例快速进行性感音神经性听力损失患者进行了异常免疫生物学检测。在排除已知病因后，他们接受了非特异性检测（血沉、电泳、免疫球蛋白、循环免疫复合物、冷球蛋白、补体系统、自身抗体）以及内耳特异性检测（通过间接免疫荧光试验检测抗人耳蜗抗体和针对人内耳混合抗原的淋巴细胞转化试验）。超过50%的病例发现有非特异性炎症综合征，30%的病例内耳特异性检测呈阳性。在特异性检测呈阳性的患者中，100%接受皮质类固醇治疗后听力有显著改善，而在检测结果为阴性的患者中这一比例为50%。根据免疫生物学检测结果，建议采用一种治疗方案。
