[应用抗促肾上腺皮质激素抗体的免疫荧光技术在三例无皮质醇增多症的垂体“嫌色”腺瘤中获得的结果的分离；超微结构研究（作者译）]

[Dissociation of results obtained with an immunofluorescence technique by using anti-ACTH antibodies in three cases of pituitary "chromophobe" adenoma without hypercorticism; ultrastructural study (author's transl)].

作者信息

Tramu G, Beauvillain J C, Mazzuca M, Fossati P, Martin-Linquette A, Christiaens J L

出版信息

Ann Endocrinol (Paris). 1976 Jan-Feb;37(1):55-6.

Abstract

Morphological studies of 3 pituitary "chromophobe" adenoma in patients without hypercorticism show positive immunofluorescenct cells with anti alpha, 17-39 ACTH antibody which are not revealed with anti beta, 1-24 ACTH antibody. These cells observed at the ultrastructural level contain secretory granules of 1,000 to 1,500 A in diameter. The existence in these cells of a substance having an immunological relationship with ACTH without biological activity is discussed.

摘要

对3例无皮质醇增多症患者的垂体“嫌色”腺瘤进行的形态学研究显示，用抗α-促肾上腺皮质激素（ACTH）17 - 39抗体检测到呈阳性免疫荧光的细胞，而用抗β-促肾上腺皮质激素1 - 24抗体则未检测到。在超微结构水平观察到这些细胞含有直径为1000至1500埃的分泌颗粒。文中讨论了这些细胞中存在一种与促肾上腺皮质激素有免疫关系但无生物活性的物质。

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