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嗜碱性和嫌色性垂体腺瘤的免疫细胞化学相似性。13例病例的光镜和电镜研究(作者译)

[Immunocytochemical similarities between basophilic and chromophobe pituitary adenomas. Light and electron microscopic study of 13 cases (author's transl)].

作者信息

Hassoun J, Charpin C, Jaquet P, Oliver C, Lissitzky J C, Grisoli F, Toga M

出版信息

Ann Endocrinol (Paris). 1979;40(6):559-60.

PMID:232835
Abstract

ACTH, beta MSH, beta LPH, beta endorpSin, leucine and methionine enkephalin activities were tested in four Cushing pituitary basophilic adenomas and nine "chromophobe" adenomas with immunoperoxidase methods. The antisera gave various positive reactions in both of these groups. ACTH, alpha MSH and enkephalins were predominant. The reason why these hormones are clinically silent in "chromophobe" or, even, basophilic adenomas is still to be elucidated.

摘要

采用免疫过氧化物酶法检测了4例库欣垂体嗜碱性腺瘤和9例“嫌色细胞”腺瘤中的促肾上腺皮质激素(ACTH)、β-促黑素(β-MSH)、β-促脂解素(β-LPH)、β-内啡肽、亮氨酸脑啡肽和甲硫氨酸脑啡肽活性。抗血清在这两组中均产生了不同的阳性反应。ACTH、α-MSH和脑啡肽占主导。这些激素在“嫌色细胞”腺瘤甚至嗜碱性腺瘤中临床上无表现的原因仍有待阐明。

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