Jennings F W
Department of Veterinary Parasitology, University of Glasgow.
Trop Med Parasitol. 1991 Jun;42(2):139-42.
In trypanosomiasis chemotherapy the main mode of action of the nitro-compounds, including the 5-nitroimidazoles or nitrofurans (nifurtimox) is to increase the oxidative stress on the organism either directly by the production of peroxides or indirectly by "futile redox cycling". If this is the case, then these nitro-compounds and the arsenicals should act in combination on the trypanothione oxidation-reduction reaction of the trypanosome. In this paper this has been demonstrated to occur with all those nitro-compounds which have exhibited reasonable trypanocidal action in monotherapy or other combination chemotherapeutic regimens. A major advantage is the short treatment period of approximately 5 days. Pretreatment with a single dose of suramin increased the efficacy of the nitroimidazole-arsenical combination.
在锥虫病化疗中，包括5-硝基咪唑或硝基呋喃（硝呋替莫）在内的硝基化合物的主要作用方式是，要么通过过氧化物的产生直接增加生物体的氧化应激，要么通过“无效氧化还原循环”间接增加氧化应激。如果是这样，那么这些硝基化合物和砷剂应该联合作用于锥虫的锥虫硫醇氧化还原反应。本文已证明，所有在单一疗法或其他联合化疗方案中表现出合理杀锥虫作用的硝基化合物都会出现这种情况。一个主要优点是治疗期短，约为5天。单剂量苏拉明预处理可提高硝基咪唑-砷剂联合用药的疗效。
