Ozoemena Kenneth I, Stefan Raluca-Ioana, van Staden Jacobus F, Aboul-Enein Hassan Y
Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa.
Talanta. 2004 Mar 10;62(4):681-5. doi: 10.1016/j.talanta.2003.08.035.
Enantioselective, potentiometric membrane electrodes (EPMEs) based on carbon paste impregnated with different maltodextrins {dextrose equivalent (DE) 4.0-7.0 (I), 13.0-17.0 (II) and 16.5-19.5 (III)} as chiral selectors for the assay of S-perindopril is described. The proposed electrodes could be reliably employed in the assay of S-perindopril raw material and from its pharmaceutical formulation, Coversyl((R)) tablets. The electrode based on maltodextrin (I) showed the best enantioselectivity and time-stability. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper.
描述了基于浸渍不同麦芽糊精（葡萄糖当量（DE）4.0 - 7.0（I）、13.0 - 17.0（II）和16.5 - 19.5（III））的碳糊作为手性选择剂的对映选择性电位膜电极（EPMEs），用于测定S - 培哚普利。所提出的电极可可靠地用于S - 培哚普利原料药及其药物制剂Coversyl((R))片剂的测定。基于麦芽糊精（I）的电极表现出最佳的对映选择性和时间稳定性。电极表面通过在氧化铝纸上简单抛光即可轻松再生。
