Stefan van Staden Raluca-Ioana, Rat'ko Alexander A
Department of Chemistry, University of Pretoria, Pretoria, South Africa.
Talanta. 2006 Jul 15;69(5):1049-53. doi: 10.1016/j.talanta.2005.12.022. Epub 2006 Jan 19.
Two enantioselective, potentiometric membrane electrodes based on alpha- and gamma-cyclodextrins were proposed for the assay of R-baclofen. The slopes of the electrodes were 59.50 and 51.00 mV/pR-baclofen for alpha- and gamma-cyclodextrin-based electrodes, respectively. The detection limits of the proposed electrodes were 7 x 10(-9)mol l(-1) for alpha-cyclodextrin-based electrode and 1.44 x 10(-10)mol l(-1) for gamma-cyclodextrin-based electrode. The enantioselectivity was determined over S-baclofen. The proposed electrodes can be employed for the assay of R-baclofen raw materials and its pharmaceutical formulation, Norton-Baclofen tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.
提出了两种基于α-和γ-环糊精的对映体选择性电位膜电极用于测定R-巴氯芬。基于α-环糊精和γ-环糊精的电极，其斜率分别为59.50和51.00 mV/pR-巴氯芬。所提出电极的检测限，基于α-环糊精的电极是7×10⁻⁹ mol/L，基于γ-环糊精的电极是1.44×10⁻¹⁰ mol/L。测定了对S-巴氯芬的对映体选择性。所提出的电极可用于测定R-巴氯芬原料药及其药物制剂诺顿巴氯芬片。电极表面稳定，通过在氧化铝纸上抛光可轻松再生。
