Fei Junjie, Wu Kangbing, Wang Fang, Hu Shengshui
Department of Chemistry, Wuhan University, Wuhan 430072, P.R. China; College of Chemistry, Xiangtan University, Xiangtan, 411105, P.R. China.
Talanta. 2005 Feb 28;65(4):918-24. doi: 10.1016/j.talanta.2004.08.015.
This paper describes glucose nanosensors based on the co-electrodeposition of a poly(vinylimidazole) complex of Os(bpy)(2)Cl and glucose oxidase (GOD) on a low-noise carbon fiber nanoelectrodes (CFNE). The SEM image shows that the osmium redox polymer/enzyme composite film is uniform. The film modified CFNE exhibits the classical features of a kinetically fast redox couple bound to the electrode surface. A strong and stable electrocatalytic current is observed in the presence of glucose. Under the optimal experimental conditions, the nanosensor offers a highly sensitive and rapid response to glucose at an operating potential of 0.22V. A wide linear dynamic rang of 0.01-15mM range was achieved with a detection limit of 0.004mM. Compared with the conventional gold electrode, the nanosensor possessed higher sensitivity and longer stability. Successful attempts were made in real time monitoring rabbit blood glucose levels.
