抗氧化治疗对高同型半胱氨酸血症诱导的心肌纤维化和舒张功能障碍的影响。
Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunction.
作者信息
Joseph Jacob, Joseph Lija, Devi Sulochana, Kennedy Richard H
机构信息
Department of Medicine, VA Boston Healthcare System, West Roxbury, Massachusetts, USA.
出版信息
J Heart Lung Transplant. 2008 Nov;27(11):1237-41. doi: 10.1016/j.healun.2008.07.024. Epub 2008 Sep 21.
BACKGROUND
Recent studies demonstrate that hyperhomocysteinemia is a risk factor for heart failure. Oxidant stress is a major mediator of the pathogenic effects of hyperhomocysteinemia.
METHODS
We utilized a rat model of diet-induced hyperhomocysteinemia to examine whether treatment with an anti-oxidant vitamin (C&E) combination will prevent hyperhomocysteinemia-induced myocardial fibrosis.
RESULTS
Dietary anti-oxidant therapy attenuated hyperhomocysteinemia-induced increases in myocardial oxidant stress and myocardial fibrosis, and diastolic dysfunction.
CONCLUSIONS
Hyperhomocysteinemia acts via oxidant stress to promote myocardial fibrosis and dysfunction. Dietary anti-oxidant therapy could be an important preventive and therapeutic strategy in diastolic heart failure.
背景
近期研究表明，高同型半胱氨酸血症是心力衰竭的一个危险因素。氧化应激是高同型半胱氨酸血症致病作用的主要介导因素。
方法
我们利用饮食诱导的高同型半胱氨酸血症大鼠模型，来研究抗氧化维生素（C和E）联合治疗是否能预防高同型半胱氨酸血症诱导的心肌纤维化。
结果
饮食抗氧化治疗减轻了高同型半胱氨酸血症诱导的心肌氧化应激增加、心肌纤维化及舒张功能障碍。
结论
高同型半胱氨酸血症通过氧化应激促进心肌纤维化和功能障碍。饮食抗氧化治疗可能是舒张性心力衰竭重要的预防和治疗策略。
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