Marcelli F, Robin G, Lefebvre-Khalil V, Marchetti C, Lemaitre L, Mitchell V, Rigot J-M
Service d'andrologie, hôpital Calmette, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
Prog Urol. 2008 Nov;18(10):657-62. doi: 10.1016/j.purol.2008.04.022. Epub 2008 Jun 30.
Cryptorchidism is a common and possible etiology of male infertility.
This is a retrospective study of 142 azoospermic men with history of cryptorchidism. A testicular sperm extraction (TESE) was performed for each of them, between 1995 and 2005, to realize in vitro fecundation with intracytoplasmic sperm injection (ICSI).
We studied the clinical pattern (age at the treatment, unilateral or bilateral cryptorchidism), hormonal levels (total testosterone and FSH) and ultrasound examinations in this population. Then, we studied the rates of successful TESE according to these various characteristics.
The main origin of azoospermia is non obstructive (secretory). A great majority of the patients (71.8%) has benefited of an orchidopexy before the age of 10 years which does not seem to represent a factor of better forecast of surgical extraction of sperm cells. In the subgroup of the bilateral cryptorchidy, the rate of extraction was 63% (55/87). In the subgroup of the one-sided cryptorchidy, it was 61.9% (36/42).
For us, history of cryptorchidism is an etiology of good prognosis for azoospermia, since the rate of TESE with positive sperm retrieval is 65%. In our population, the subgroups of patients whose FSH is normal and/or whose testicular volume is higher than 10 cm3 are those whose forecast is still better, because the rate of TESE with positive sperm retrieval is 75%.
隐睾症是男性不育的常见且可能病因。
这是一项对142例有隐睾症病史的无精子症男性的回顾性研究。在1995年至2005年期间,对他们每人均进行了睾丸精子提取(TESE),以通过卵胞浆内单精子注射(ICSI)实现体外受精。
我们研究了该人群的临床模式(治疗时的年龄、单侧或双侧隐睾症)、激素水平(总睾酮和促卵泡激素)及超声检查。然后,我们根据这些不同特征研究了TESE成功的比率。
无精子症的主要起源是非梗阻性(分泌性)。绝大多数患者(71.8%)在10岁前接受了睾丸固定术,这似乎并非精子细胞手术提取预后更好的因素。在双侧隐睾症亚组中,提取率为63%(55/87)。在单侧隐睾症亚组中,提取率为61.9%(36/42)。
对我们而言,隐睾症病史是无精子症预后良好的一个病因,因为精子回收阳性的TESE率为65%。在我们的人群中,促卵泡激素正常和/或睾丸体积大于10立方厘米的患者亚组预后更佳,因为精子回收阳性的TESE率为75%。