Gomes M da S, Bernardi M M, Spinosa H de S
Applied Pharmacology and Toxicology Laboratory, School of Veterinary Medicine, University of Sao Paulo, Brazil.
Vet Hum Toxicol. 1991 Aug;33(4):315-7.
We investigated the prenatal effects of cyhalothrin exposure on the physical and behavioral development of infant and adult rats. Female rats were treated by dermal exposure with a 0.018% cyhalothrin aqueous solution (1 ml/d) or the cyhalothrin vehicle during their entire pregnancy. The pesticide delayed development of fur, the ear and eye openings and descent of the testes in the offspring. The exploratory behavior of the rats prenatally exposed to cyhalothrin decreased. No differences were observed between control and experimental animals in inhibitory avoidance tasks at 90 d of age in open field activity. Alterations in physical parameters and possible effects of the pesticide on epidermal growth factor and hormonal levels were considered. Since no overt of signs of maternal or neonatal toxicity were observed, the decrease in adult motivational behavior was attributed to a specific effect of the pesticide administered during the prenatal period. We concluded that prenatal cyhalothrin exposure induced subtle and persistent changes in the physical development and behavior of rats.
我们研究了氯氟氰菊酯暴露对幼鼠及成年大鼠身体和行为发育的产前影响。在整个孕期，对雌性大鼠进行皮肤暴露处理，分别给予0.018%氯氟氰菊酯水溶液（1毫升/天）或氯氟氰菊酯溶媒。该农药延缓了后代皮毛、耳眼开口及睾丸下降的发育。产前暴露于氯氟氰菊酯的大鼠的探索行为减少。在90日龄时，旷场活动中抑制性回避任务方面，对照动物与实验动物之间未观察到差异。考虑了身体参数的改变以及该农药对表皮生长因子和激素水平的可能影响。由于未观察到母体或新生儿毒性的明显迹象，成年期动机行为的减少归因于产前给予该农药的特定作用。我们得出结论，产前暴露于氯氟氰菊酯会在大鼠的身体发育和行为方面引起细微且持续的变化。
