Sitarek K, Barański B
Department of Occupational Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
Pol J Occup Med. 1990;3(3):285-92.
Female rats were given by gavage every other day from days 2 to 20 of gestation an aqueous solution of trioxane at daily doses equal to 0.025; 0.075 and 0.15 LD50 (0.19: 0.58 and 1.16 g/kg). Maternal exposure to trioxane at the highest dose resulted in death of most neonates a few days after birth. Viability and postnatal growth of the offspring of dams that were given 0.19 and 0.58 g/kg were not affected. Transitional depression of exploratory locomotor activity in female offspring and a decrease of active avoidance acquisition were observed in adult male and female offspring from the 0.58 g/kg group, whereas a dose of 0.19 g trioxane /kg did not affect the behavioral performance of progeny.
在妊娠第2天至第20天，每隔一天给雌性大鼠灌胃三恶烷水溶液，日剂量分别相当于0.025、0.075和0.15 LD50（0.19、0.58和1.16克/千克）。母体以最高剂量接触三恶烷导致大多数新生儿在出生后几天死亡。给予0.19和0.58克/千克剂量的母鼠所产后代的活力和出生后生长未受影响。在0.58克/千克组的成年雄性和雌性后代中，观察到雌性后代的探索性运动活动出现短暂抑制，主动回避学习能力下降，而0.19克三恶烷/千克的剂量并未影响后代的行为表现。
