Portales-Casamar Elodie, Arenillas David, Lim Jonathan, Swanson Magdalena I, Jiang Steven, McCallum Anthony, Kirov Stefan, Wasserman Wyeth W
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Nucleic Acids Res. 2009 Jan;37(Database issue):D54-60. doi: 10.1093/nar/gkn783. Epub 2008 Oct 29.
The PAZAR database unites independently created and maintained data collections of transcription factor and regulatory sequence annotation. The flexible PAZAR schema permits the representation of diverse information derived from experiments ranging from biochemical protein-DNA binding to cellular reporter gene assays. Data collections can be made available to the public, or restricted to specific system users. The data 'boutiques' within the shopping-mall-inspired system facilitate the analysis of genomics data and the creation of predictive models of gene regulation. Since its initial release, PAZAR has grown in terms of data, features and through the addition of an associated package of software tools called the ORCA toolkit (ORCAtk). ORCAtk allows users to rapidly develop analyses based on the information stored in the PAZAR system. PAZAR is available at http://www.pazar.info. ORCAtk can be accessed through convenient buttons located in the PAZAR pages or via our website at http://www.cisreg.ca/ORCAtk.
PAZAR数据库整合了独立创建和维护的转录因子及调控序列注释数据集。灵活的PAZAR模式允许呈现从生化蛋白质-DNA结合到细胞报告基因检测等各种实验得出的不同信息。数据集可以向公众开放,也可以限制特定系统用户访问。受购物中心启发的系统中的数据“精品店”有助于基因组学数据分析以及创建基因调控预测模型。自首次发布以来,PAZAR在数据量、功能方面都有所增长,并且通过添加一个名为ORCA工具包(ORCAtk)的相关软件工具包得以扩展。ORCAtk允许用户基于存储在PAZAR系统中的信息快速开发分析方法。可通过http://www.pazar.info访问PAZAR。可以通过PAZAR页面上的便捷按钮或通过我们的网站http://www.cisreg.ca/ORCAtk访问ORCAtk。