Slugen I, Bucek J, Kovác A, Slugenová E, Pauer M, Fiala P
Katedra patológie ILF Bratislava.
Vnitr Lek. 1991 Jun;37(6):557-62.
In a total of 1499 representative renal biopsies 30 displayed morphological changes suggesting diabetic nephropathy. Six patients had clinically diagnosed diabetes at the time of biopsy, 20 according to the bioptic finding, and in four patients the examination did not confirm diabetes. The authors describe the morphological vascular changes in particular the cumulation of masses resembling the mesangial matrix and basal membranes, as well as hyaline lesions, their development, site and combinations. In the author's opinion the most reliable sign of early diabetic nephropathy is thickening of the glomerular basal membrane. They draw attention to the non-specific character of the morphological finding and the necessity to diagnose diabetes mellitus by clinical and in particular by laboratory methods.
在总共1499份具有代表性的肾活检样本中，有30份显示出提示糖尿病肾病的形态学改变。6例患者在活检时临床诊断为糖尿病，20例根据活检结果诊断为糖尿病，4例患者的检查未证实患有糖尿病。作者描述了形态学上的血管变化，特别是类似系膜基质和基底膜的物质堆积，以及玻璃样病变、它们的发展、部位和组合。作者认为，早期糖尿病肾病最可靠的迹象是肾小球基底膜增厚。他们提请注意形态学发现的非特异性特征以及通过临床尤其是实验室方法诊断糖尿病的必要性。
