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[支持性护理。肺癌的内镜治疗]

[Supportive care. Endoscopic treatments for lung cancer].

作者信息

Vergnon J-M

机构信息

Service de Pneumologie et d'Oncologie Thoracique, Hôpital Nord CHU de Saint-Etienne, Saint-Etienne cedex 2, France.

出版信息

Rev Mal Respir. 2008 Oct;25(8 Pt 2):3S160-6.

Abstract

Interventional bronchoscopy is indicated both in advanced stages of lung cancer with severe airway obstruction or in early stages. In the first situation, the goal is palliative and the treatment is based on a mechanical debulking with a rigid bronchoscope to core out the tumour and/or to insert stent in cases of external compression. A dramatic improvement is currently observed. Interventional bronchoscopy is mandatory before chemotherapy or radiotherapy in patients either with a symptomatic airway obstruction or with an obstruction more than 50% of the lumen of a major bronchus. In some cases, a synergic action between therapeutic bronchoscopy and conventional radio-chemotherapy is observed. In early stages (superficial lung cancers) the treatment can be curative with methods sparing the bronchial wall, such as cryotherapy, electrocautery in soft mode, photodynamic therapy or brachytherapy. In these superficial lesions, synchronous tumours are frequent and 5% per year of metachronous lesions are observed in the follow-up. Thus, sparing lung parenchyma can be crucial and explains the growing role of therapeutic bronchoscopy as alternative to surgery. A curative result is obtained in about 80% of cases with these methods but a prolonged and careful bronchoscopic follow-up is mandatory.

摘要

介入性支气管镜检查适用于肺癌晚期伴有严重气道阻塞的情况,也适用于早期肺癌。在第一种情况下,目标是姑息治疗,治疗方法是使用硬支气管镜进行机械减瘤,以切除肿瘤和/或在外部压迫的情况下插入支架。目前观察到有显著改善。对于有症状性气道阻塞或主支气管管腔阻塞超过50%的患者,在化疗或放疗前必须进行介入性支气管镜检查。在某些情况下,可观察到治疗性支气管镜检查与传统放化疗之间的协同作用。在早期(浅表性肺癌),可以采用保留支气管壁的方法进行治愈性治疗,如冷冻疗法、软模式电灼、光动力疗法或近距离放射疗法。在这些浅表病变中,同步肿瘤很常见,随访中每年观察到5%的异时性病变。因此,保留肺实质可能至关重要,这也解释了治疗性支气管镜检查作为手术替代方法的作用日益增加。使用这些方法在大约80%的病例中可获得治愈性结果,但必须进行长期且仔细的支气管镜随访。

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