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[高剂量支气管内近距离放射治疗恶性气道阻塞:30例患者的首例研究]

[High dose endobronchial brachytherapy for malignant airway obstruction: first study of 30 patients].

作者信息

Yarmolovsky A, Katz A, Fenig E, Fink G, Bendayan D, Sulkes A, Kramer M R

机构信息

Institute of Pulmonology, Rabin Medical Center, Beilinson Campus, Petah Tikva.

出版信息

Harefuah. 2000 Mar 15;138(6):429-31, 520.

Abstract

Brachytherapy is especially suitable for palliative treatment of endobronchial tumors adjacent to internal organs that might be damaged by intensive external beam radiation, but are easily accessed with a flexible bronchoscope. This treatment is mostly palliative. 30 patients underwent such palliative high-dose endobronchial brachytherapy to alleviate malignant airway obstruction. With the aid of a flexible fiberoptic bronchoscope an endobronchial catheter was inserted adjacent to the tumor and treatment delivered using a 192Ir remote afterloader for 5-10 min, in 2 or 3 sessions. There was symptomatic improvement in 26 (86%) and objective improvement in 27 (90%). 1 patient died of hemoptysis.

摘要

近距离放射治疗特别适用于对邻近内部器官的支气管内肿瘤进行姑息治疗,这些内部器官可能会因高强度外照射而受损,但通过可弯曲支气管镜很容易到达。这种治疗大多是姑息性的。30例患者接受了这种姑息性高剂量支气管内近距离放射治疗以缓解恶性气道阻塞。借助可弯曲纤维支气管镜,在肿瘤附近插入支气管内导管,并使用192铱遥控后装治疗机进行治疗,每次治疗5 - 10分钟,分2或3次进行。26例(86%)有症状改善,27例(90%)有客观改善。1例患者死于咯血。

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