Shcherbakova I A, Perova N V, Sokolov E I, Shukina G N, Metel'skaia V A, Nikitina N A, Fomina V M
Vopr Med Khim. 1991 Mar-Apr;37(2):23-6.
Effects of fatty loading on patterns of the lipoprotein system were studied in blood plasma of 39 patients with ischemic heart disease and of 21 healthy volunteers and were carried out on fasting individuals within 3 and 6 hrs after the loading. Alterations were detected in the lipoprotein system of the patients as compared with healthy persons. In the patients with ischemic heart disease content of apoI was not increased while subfraction of high density lipoproteins HDL3b was elevated within 3 hrs and cholesterol content was decreased within 6 hrs after the fatty loading. These alterations appear to be applicable as tests for detection of latent atherogenous defects in the HDL system.
在39例缺血性心脏病患者和21名健康志愿者的血浆中，研究了脂肪负荷对脂蛋白系统模式的影响，并在负荷后3小时和6小时内对空腹个体进行了研究。与健康人相比，患者的脂蛋白系统出现了变化。在缺血性心脏病患者中，载脂蛋白I的含量没有增加，而高密度脂蛋白HDL3b的亚组分在脂肪负荷后3小时内升高，胆固醇含量在6小时内降低。这些变化似乎可作为检测高密度脂蛋白系统潜在动脉粥样硬化缺陷的测试方法。
