自噬性细胞死亡：一个名不副实的故事。
Autophagic cell death: the story of a misnomer.
作者信息
Kroemer Guido, Levine Beth
机构信息
Institut Gustave Roussy, F-94805 Villejuif, France.
出版信息
Nat Rev Mol Cell Biol. 2008 Dec;9(12):1004-10. doi: 10.1038/nrm2529. Epub 2008 Oct 30.
Abstract
Dying cells often display a large-scale accumulation of autophagosomes and hence adopt a morphology called autophagic cell death. In many cases, it is agreed that this autophagic cell death is cell death with autophagy rather than cell death by autophagy. Here, we evaluate the accumulating body of literature that argues that cell death occurs by autophagy. We also list the caveats that must be considered when deciding whether or not autophagy is an important effector mechanism of cell death.
摘要
濒死细胞常常会出现自噬体的大规模积累，从而呈现出一种被称为自噬性细胞死亡的形态。在许多情况下，人们一致认为这种自噬性细胞死亡是伴有自噬的细胞死亡，而非由自噬导致的细胞死亡。在此，我们评估了大量主张细胞死亡是由自噬引起的文献。我们还列出了在判定自噬是否为细胞死亡的重要效应机制时必须考虑的注意事项。
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本文引用的文献
1
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.
Cell Death Differ. 2009 Jan;16(1):3-11. doi: 10.1038/cdd.2008.150. Epub 2008 Oct 10.
2
Does autophagy have a license to kill mammalian cells?
Cell Death Differ. 2009 Jan;16(1):12-20. doi: 10.1038/cdd.2008.101. Epub 2008 Jul 4.
3
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.
Cancer Cell. 2008 Jul 8;14(1):90-102. doi: 10.1016/j.ccr.2008.06.004.
4
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis.
Mol Cancer Res. 2008 Jun;6(6):965-77. doi: 10.1158/1541-7786.MCR-07-2036.
5
M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models.
PLoS One. 2008 May 28;3(5):e2275. doi: 10.1371/journal.pone.0002275.
6
A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.
J Biol Chem. 2008 Jul 4;283(27):18678-84. doi: 10.1074/jbc.M801855200. Epub 2008 Apr 23.
7
Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells.
Autophagy. 2008 Jul;4(5):669-79. doi: 10.4161/auto.6083. Epub 2008 Apr 10.
8
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells.
Cell Death Differ. 2008 Aug;15(8):1318-29. doi: 10.1038/cdd.2008.51. Epub 2008 Apr 18.
9
Identification of RIP1 kinase as a specific cellular target of necrostatins.
Nat Chem Biol. 2008 May;4(5):313-21. doi: 10.1038/nchembio.83.
10
Autophagy fights disease through cellular self-digestion.
Nature. 2008 Feb 28;451(7182):1069-75. doi: 10.1038/nature06639.
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