Fooanant Supranee, Chaiyasate Saisawat, Roongrotwattanasiri Kannika
Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Med Assoc Thai. 2008 Oct;91(10):1558-63.
To compare the efficacy of dexpanthenol spray and saline irrigation in the postoperative care of sinusitis patients following endoscopic sinus surgery (ESS).
One hundred twenty eight sinusitis patients undergoing ESS were randomly allocated to receive dexpanthenol spray (Mar plus) or saline irrigation twice a day for 4 weeks after the operation. Total nasal symptom score, crusting, infection, compliance, and patient satisfaction were evaluated at 1, 2-3, 4-6, and 12 weeks. Mucociliary clearance was assessed with the saccharin test before ESS and at the last visit. One hundred ten patients remained at the present study termination. Chi-square test and Mann-Whitney U test were employed.
Total nasal symptom score, mucociliary clearance, and infection improved in both groups after the operation. The dexpanthenol group resulted in a better mucociliary clearance than saline irrigation (9.93 +/- 6.04 vs. 12.38 +/- 9.32 min, p = 0.43). Saline irrigation resulted in a greater reduction of post nasal drip than dexpanthenol at the first visit (74% vs. 87%, p = 0.04). Compliance and patient satisfaction were comparable.
The efficacy of dexpanthenol was comparable to nasal saline irrigation in the postoperative care of sinusitis patients following endoscopic sinus surgery. Dexpanthenol is an alternative treatment, which may be useful in young children and complicated cases.
比较右泛醇喷雾剂和生理盐水冲洗在鼻窦炎患者鼻内镜手术（ESS）术后护理中的疗效。
128例接受ESS的鼻窦炎患者被随机分配，术后4周每天接受两次右泛醇喷雾剂（Mar plus）或生理盐水冲洗。在术后1、2 - 3、4 - 6和12周评估总鼻症状评分、结痂、感染、依从性和患者满意度。在ESS术前和末次随访时用糖精试验评估黏液纤毛清除功能。本研究结束时110例患者仍在研究中。采用卡方检验和曼 - 惠特尼U检验。
两组术后总鼻症状评分、黏液纤毛清除功能和感染情况均有改善。右泛醇组的黏液纤毛清除功能优于生理盐水冲洗组（9.93±6.04分钟 vs. 12.38±9.32分钟，p = 0.43）。在首次随访时，生理盐水冲洗比右泛醇更能显著减少鼻后滴漏（74% vs. 87%，p = 0.04）。依从性和患者满意度相当。
在鼻窦炎患者鼻内镜手术后的护理中，右泛醇的疗效与鼻腔生理盐水冲洗相当。右泛醇是一种替代治疗方法，可能对幼儿和复杂病例有用。
