Deceuninck Geneviève, Boucher Renée-Myriam, De Wals Philippe, Ouakki Manale
Public Health Research Unit, Quebec University Hospital Centre, Quebec City, Canada.
Can J Neurol Sci. 2008 Sep;35(4):472-5. doi: 10.1017/s0317167100009136.
In the province of Quebec, a population-based study of Guillain-Barré syndrome (GBS) was conducted at the time of a mass immunization campaign against meningococcal disease, in 2001.
The study population included residents aged 2 months to 20 years observed from November 1st, 2000 to December 31, 2002, representing 4,075,465 person-years of observation. GBS cases were identified in the provincial hospital database Med-Echo and medical records were reviewed.
Thirty-three incident GBS cases were identified, including 27 cases of acute inflammatory demyelinating polyradiculopathy. The overall GBS incidence rate was 0.8/100,000 person-years, higher in persons aged 1 to 4 years (2.1/100,000) than in those 5 years or more (0.6/100,000). There was a female preponderance and no significant seasonal variation. All patients survived.
Results could be used to interpret reports of adverse events associated with the introduction of new vaccines in this age-group in Canada.
2001年，在魁北克省开展了一项针对吉兰-巴雷综合征（GBS）的基于人群的研究，当时正在进行一场针对脑膜炎球菌病的大规模免疫接种运动。
研究人群包括2000年11月1日至2002年12月31日期间观察到的2个月至20岁的居民，代表4,075,465人年的观察期。在省级医院数据库Med-Echo中识别出GBS病例，并对病历进行了审查。
共识别出33例新发GBS病例，其中27例为急性炎症性脱髓鞘性多发性神经根病。GBS的总体发病率为0.8/100,000人年，1至4岁人群（2.1/100,000）高于5岁及以上人群（0.6/100,000）。女性占多数，且无明显季节性变化。所有患者均存活。
研究结果可用于解释加拿大该年龄组引入新疫苗相关不良事件的报告。
