Nomura Takashi, Inoue Yuichi, Kusumi Masayoshi, Uemura Yusuke, Nakashima Kenji
Department of Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago, Japan.
Mov Disord. 2008 Dec 15;23(16):2363-9. doi: 10.1002/mds.22274.
To assess the prevalence and clinical significance of restless legs syndrome (RLS) in a Japanese population, we carried out a community-based survey in a rural area of Japan. We sent questionnaires requesting information on demographics, the Center for Epidemiological Studies Depression scale, the Short Form-8, the Pittsburgh Sleep Quality Index, the National Institutes of Health/International RLS Study Group (IRLSSG) consensus questionnaire, and the IRLSSG severity scale for RLS (IRLS) to 5,528 eligible adult residents in the town of Daisen in the Tottori prefecture of Japan. Next, we performed telephone interviews to identify subjects with probable RLS. Of the 2,812 subjects (51.1%) who gave complete answers on the IRLSSG questionnaire, 50 (1.8%) were judged as RLS positive. The prevalence of RLS was significantly higher in women than in men, and significantly lower in individuals 60 years of age or older. Multiple logistic regression analysis revealed that the existence of RLS was significantly associated with depression, lowered mental quality of life, and sleep disturbances. The prevalence of RLS in adult Japanese populations may be lower than that reported in Caucasian populations. However, in a group of Japanese subjects, RLS had a significant impact on daytime functioning as well as subjective sleep quality.
为评估日本人群中不宁腿综合征（RLS）的患病率及临床意义，我们在日本农村地区开展了一项基于社区的调查。我们向日本鸟取县大山镇5528名符合条件的成年居民发放问卷，询问人口统计学信息、流行病学研究中心抑郁量表、简短健康调查问卷-8、匹兹堡睡眠质量指数、美国国立卫生研究院/国际不宁腿综合征研究组（IRLSSG）共识问卷以及IRLSSG不宁腿综合征严重程度量表（IRLS）相关信息。接下来，我们进行电话访谈以确定可能患有RLS的受试者。在2812名对IRLSSG问卷给出完整回答的受试者（占51.1%）中，50名（占1.8%）被判定为RLS阳性。RLS的患病率在女性中显著高于男性，在60岁及以上个体中显著更低。多因素逻辑回归分析显示，RLS的存在与抑郁、心理生活质量降低以及睡眠障碍显著相关。日本成年人群中RLS的患病率可能低于白种人群中报告的患病率。然而，在一组日本受试者中，RLS对日间功能以及主观睡眠质量有显著影响。
