Lin Sheng-Jie, Tang Shang-Ching Joy, Lee Yu-Chia, Liu Ting-Yu, Huang Ting-Chun, Yu Rwei-Ling, Tan Chun-Hsiang
School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Front Med (Lausanne). 2022 Nov 14;9:951762. doi: 10.3389/fmed.2022.951762. eCollection 2022.
Individuals with chronic viral hepatitis are at increased risk of experiencing poor sleep quality and sleep disturbances. However, it remains unclear whether the sleep disorders associated with viral hepatitis are secondary to the comorbidities related to viral hepatitis or the direct effect of hepatitis viruses on sleep. This study investigated the direct impact of viral hepatitis B and C on sleep quality.
Individuals with viral hepatitis B or C and their healthy counterparts were recruited for the present study, and they were evaluated with the Parkinson's Disease Sleep Scale-2, the Epworth Sleepiness Scale, and the Pittsburgh Sleep Quality Index in the absence of common comorbidities associated with viral hepatitis.
Neither hepatitis B nor hepatitis C was found to cause significant differences in insomnia symptoms or excessive daytime sleepiness. However, individuals with hepatitis C, but not hepatitis B, tended to be less likely to experience restlessness of the legs or arms at night.
This study suggests that hepatitis viruses B and C may not cause a significant impact on sleep quality and related disorders directly. Sleep disturbances in individuals with chronic viral hepatitis may instead be attributable to hepatic decompensation or the comorbid factors associated with viral hepatitis.
慢性病毒性肝炎患者出现睡眠质量差和睡眠障碍的风险增加。然而，与病毒性肝炎相关的睡眠障碍是继发于与病毒性肝炎相关的合并症，还是肝炎病毒对睡眠的直接影响，仍不清楚。本研究调查了乙型和丙型病毒性肝炎对睡眠质量的直接影响。
招募乙型或丙型病毒性肝炎患者及其健康对照，在不存在与病毒性肝炎相关的常见合并症的情况下，用帕金森病睡眠量表-2、爱泼华嗜睡量表和匹兹堡睡眠质量指数对他们进行评估。
未发现乙型肝炎和丙型肝炎在失眠症状或日间过度嗜睡方面引起显著差异。然而，丙型肝炎患者（而非乙型肝炎患者）夜间出现腿部或手臂不安的可能性较小。
本研究表明，乙型和丙型肝炎病毒可能不会直接对睡眠质量和相关障碍造成显著影响。慢性病毒性肝炎患者的睡眠障碍可能反而归因于肝失代偿或与病毒性肝炎相关的合并因素。
