Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400 019, India.
J Org Chem. 2008 Dec 5;73(23):9473-5. doi: 10.1021/jo801580g.
Alpha,alpha-disubstituted acetamides undergo oxidative dehomologation to give one-carbon-shorter ketones when reacted with a hypervalent iodine (lambda(5)) reagent in combination with tetraethylammonium bromide (TEAB) in various solvents. In further studies, one such combination of a hypervalent iodine (lambda(5)) reagent, o-iodoxybenzoic acid, and TEAB has been established as a new, mild, efficient, and general method for the transformation.
α,α-二取代乙酰胺与高价碘（λ(5)）试剂在各种溶剂中反应，并结合四乙基溴化铵（TEAB），会发生氧化去同系化反应，生成一个碳原子数更短的酮。在进一步的研究中，确定了高价碘（λ(5)）试剂邻碘酰苯甲酸与 TEAB 的这种组合是一种新的、温和、高效、通用的转化方法。
