Yang Ji-Rong, Wu Ho-Sheng, Chiang Chuen-Sheue, Mu Jung-Jung
Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan.
BMC Infect Dis. 2008 Oct 31;8:151. doi: 10.1186/1471-2334-8-151.
There has been a marked increase in the incidence of, and concern regarding, human Campylobacter jejuni and C. coli infections worldwide during the last decade. As the highest infectious disease control apparatus in Taiwan, we aimed to describe the character of Campylobacter isolates from infected children, as well as basic information about the patients, from December 2003 to February 2005.
A total of 894 fecal specimens were collected by several clinics and hospitals from children who had diarrhea, followed by plating onto selective media. Drug susceptibility test of the isolates from these specimens were conducted by disc diffusion method and their serotypes were also studied using commercial antisera made in Japan.
The isolation rate of Campylobacter during these 15 months was 6.8% and was higher in winter (11.1%) than in other seasons. C. jejuni was the most prevalent (95.1%) species in northern Taiwan, comparable to other developed countries. Among the 61 Campylobacter isolates, most were resistant to tetracycline (93.4%), nalidixic acid (91.8%), ciprofloxacin (90.2%), and ampicillin (85.5%). Erythromycin-resistant isolates represented 3.3% of all isolates, suggesting that this drug may be the first choice for treatment. The serotypes of the 61 isolates were demonstrated and only 41.4% were typable.
In this study, the Taiwan CDC provided an epidemiological analysis of Campylobacter infection, including the isolation rate, age, seasonal distribution, antimicrobial drug susceptibility patterns, and serotypes of the isolates from pediatric patients in northern Taiwan from 2003 to 2005.
在过去十年中，全球人类空肠弯曲菌和结肠弯曲菌感染的发病率显著上升，引发了广泛关注。作为台湾最高级别的传染病控制机构，我们旨在描述2003年12月至2005年2月期间从感染儿童中分离出的弯曲菌菌株的特征以及患者的基本信息。
几家诊所和医院从腹泻儿童中收集了总共894份粪便标本，随后接种到选择性培养基上。采用纸片扩散法对这些标本中分离出的菌株进行药敏试验，并使用日本生产的商用抗血清研究其血清型。
在这15个月期间，弯曲菌的分离率为6.8%，冬季（11.1%）高于其他季节。空肠弯曲菌是台湾北部最常见的菌种（95.1%），与其他发达国家相当。在61株弯曲菌分离株中，大多数对四环素（93.4%）、萘啶酸（91.8%）、环丙沙星（90.2%）和氨苄西林（85.5%）耐药。耐红霉素的分离株占所有分离株的3.3%，表明该药可能是治疗的首选药物。对61株分离株的血清型进行了鉴定，只有41.4%可分型。
在本研究中，台湾疾病控制中心提供了弯曲菌感染的流行病学分析，包括2003年至2005年台湾北部儿科患者分离株的分离率、年龄、季节分布、抗菌药物敏感性模式和血清型。
