Castro-Rueda Hernan, Kavanaugh Arthur
Center for Innovative Therapy, Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093-0943, USA.
Curr Pain Headache Rep. 2008 Dec;12(6):412-7. doi: 10.1007/s11916-008-0070-x.
NSAIDs still remain the initial therapeutic modality for psoriatic arthritis and inflammatory spondylitis. Disease-modifying antirheumatic drugs have only been proven to be useful in peripheral arthritis, without efficacy in axial inflammatory spondylitis. In recent years, the introduction of tumor necrosis alpha inhibitors into clinical practice has produced a substantial impact in both peripheral and axial disease, with improvement in pain, function, and quality of life. Factors such as cost-effectiveness and safety will need to be better characterized over time.
非甾体抗炎药仍然是银屑病关节炎和炎性脊柱关节炎的初始治疗方式。改善病情抗风湿药仅被证明对周围性关节炎有效，对轴性炎性脊柱关节炎无效。近年来，肿瘤坏死因子α抑制剂引入临床实践后，对周围性和轴性疾病均产生了重大影响，疼痛、功能及生活质量均有所改善。随着时间推移，成本效益和安全性等因素将需要得到更充分的评估。
