毒扁豆碱治疗阿尔茨海默病：对认知功能、通过正电子发射断层扫描分析的脑葡萄糖代谢及通过单光子发射断层扫描分析的脑血流量的影响。

Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography.

作者信息

Tune L, Brandt J, Frost J J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M F, Wagner H N

机构信息

Dementia Research Clinic, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.

出版信息

Acta Psychiatr Scand Suppl. 1991;366:61-5. doi: 10.1111/j.1600-0447.1991.tb03111.x.

DOI:10.1111/j.1600-0447.1991.tb03111.x

PMID:1897377

Abstract

The effect of acute, intravenous administration of physostigmine on measures of brain activity and cognitive functioning were investigated in 14 patients with Alzheimer's disease. Regional cerebral glucose metabolism was assessed using (18F)-fluoro-2-deoxy-D-glucose and positron emission tomography, and cerebral blood flow was assessed using 123I-iodoamphetamine single photon emission tomography. Although physostigmine enhanced cerebral blood flow in most patients, only one patient showed significant clinical improvement. This patient, however, also showed a very pronounced improvement in cerebral glucose metabolism. It is concluded that these preliminary findings hold considerable promise for our appreciation of the pathophysiology of dementing illness as well as our understanding of centrally acting compounds of interest in Alzheimer's disease.

摘要

对14例阿尔茨海默病患者研究了急性静脉注射毒扁豆碱对脑活动指标和认知功能的影响。使用（18F）-氟-2-脱氧-D-葡萄糖和正电子发射断层扫描评估局部脑葡萄糖代谢，使用123I-碘安非他明单光子发射断层扫描评估脑血流量。虽然大多数患者毒扁豆碱增加了脑血流量，但只有1例患者有显著的临床改善。然而，该患者脑葡萄糖代谢也有非常明显的改善。得出结论，这些初步发现对于我们理解痴呆症的病理生理学以及我们对阿尔茨海默病中有意义的中枢作用化合物的认识有很大希望。