中枢胆碱能刺激对阿尔茨海默病局部脑血流的影响。

Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.

作者信息

Wilson K, Bowen D, Francis P, Tyrrell P

机构信息

Department of Psychogeriatrics, Mossley Hill Hospital, Liverpool.

出版信息

Br J Psychiatry. 1991 Apr;158:558-62. doi: 10.1192/bjp.158.4.558.

DOI:10.1192/bjp.158.4.558

PMID:2054572

Abstract

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

摘要

与对照组相比，阿尔茨海默病（AD）患者颞顶叶后部区域的局部脑血流量（rCBF）减少，这是通过锝-99m六甲基丙烯胺肟和单光子发射断层扫描确定的。用毒扁豆碱进行中枢胆碱能刺激后，AD患者颞顶叶后部区域的rCBF出现局部增加，而对照组则未出现这种情况。