中枢胆碱能刺激对阿尔茨海默病局部脑血流的影响。
Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.
作者信息
Wilson K, Bowen D, Francis P, Tyrrell P
机构信息
Department of Psychogeriatrics, Mossley Hill Hospital, Liverpool.
出版信息
Br J Psychiatry. 1991 Apr;158:558-62. doi: 10.1192/bjp.158.4.558.
PMID:2054572
Abstract
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.
摘要
与对照组相比，阿尔茨海默病（AD）患者颞顶叶后部区域的局部脑血流量（rCBF）减少，这是通过锝-99m六甲基丙烯胺肟和单光子发射断层扫描确定的。用毒扁豆碱进行中枢胆碱能刺激后，AD患者颞顶叶后部区域的rCBF出现局部增加，而对照组则未出现这种情况。
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