Kumar A, Schapiro M B, Haxby J V, Grady C L, Friedland R P
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Maryland.
J Psychiatr Res. 1990;24(2):97-109. doi: 10.1016/0022-3956(90)90050-z.
Three subjects with dementia of the Alzheimer type (DAT) with frontal lobe features of behavioral disinhibition were studied using positron emission tomography with [18F]2-fluoro-2-deoxy-D-glucose (18 FDG) and standardized neuropsychological tests. The three subjects showed significant decrements (p less than .05) in relative glucose metabolism (regional/mean gray metabolism) in the orbitofrontal, prefrontal and anterior cingulate regions when compared to healthy controls. Severity-matched subjects with DAT without the associated frontal lobe features did not show the relative reductions in glucose metabolism in these regions when compared to controls. However, on neuropsychological testing of frontal lobe cognitive functions the three subjects did not show decrements that were more severe than those shown by severity-matched DAT patients without the behavioral features. These data demonstrate physiologic dysfunction in specific cortical regions in subjects with behavioral aberrations attributed to these regions and an apparent dissociation between behavioral and cognitive functions of the frontal lobe.
使用正电子发射断层扫描技术及[18F]2-氟-2-脱氧-D-葡萄糖（18FDG）和标准化神经心理学测试，对三名患有阿尔茨海默型痴呆（DAT）且具有额叶行为抑制特征的受试者进行了研究。与健康对照组相比，这三名受试者在眶额叶、前额叶和前扣带回区域的相对葡萄糖代谢（区域/平均灰质代谢）出现了显著下降（p<0.05）。与对照组相比，患有DAT但无相关额叶特征且病情严重程度匹配的受试者在这些区域并未出现葡萄糖代谢的相对降低。然而，在额叶认知功能的神经心理学测试中，这三名受试者的功能下降程度并不比病情严重程度匹配但无行为特征的DAT患者更严重。这些数据表明，在归因于这些区域的行为异常受试者中，特定皮质区域存在生理功能障碍，并且额叶的行为和认知功能之间存在明显的分离。
