亚油酸摄入量对人体花生四烯酸形成及类二十烷酸生物合成的影响。
Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans.
作者信息
Adam O, Tesche A, Wolfram G
机构信息
Medizinische Klinik, Klinikum Innenstadt, Ludwig-Maximilians-University Munich, Germany.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):177-81. doi: 10.1016/j.plefa.2008.09.007. Epub 2008 Oct 29.
UNLABELLED
Long-chain conversion of linoleic acid (LA) and eicosanoid formation was followed in 6 healthy females who were given for 6 weeks liquid formula diets which contained no arachidonic acid but, for 2 weeks each, a LA supply of 0 energy% (en%), 4 en%, and 20 en%, respectively.
RESULTS
higher LA intake resulted in higher LA percentages in investigated lipids, but not in higher amounts of LA present in plasma cholesterol esters or phosphatidylcholine of LDL and HDL comparing liquid formula diet (LFD) 4 and LFD 20. A higher intake of LA resulted in a decrease of arachidonic acid, which was most prominent in HDL phosphatidycholine. Eicosanoids derived from cyclo-oxygenase activity were unchanged by LA intake, while an increase of cytochrome P450-dependent tetranorprostanedioic acid formation was observed with LFD 20.
CONCLUSION
LA intake of 4 en% appears to be a recommendable intake, without signs of stimulated eicosanoid biosynthesis or oxidation.
未标记
对6名健康女性进行了研究，她们接受了为期6周的液体配方饮食，该饮食不含花生四烯酸，但分别在每2周的时间内提供能量占比为0%、4%和20%的亚油酸供应。
结果
较高的亚油酸摄入量导致所研究脂质中亚油酸百分比升高，但与液体配方饮食（LFD）4和LFD 20相比，血浆胆固醇酯或低密度脂蛋白和高密度脂蛋白的磷脂酰胆碱中存在的亚油酸量并未增加。较高的亚油酸摄入量导致花生四烯酸减少，这在高密度脂蛋白磷脂酰胆碱中最为明显。来自环氧化酶活性的类二十烷酸不受亚油酸摄入量的影响，而在LFD 20中观察到细胞色素P450依赖性四去甲前列腺二酸形成增加。
结论
4%能量占比的亚油酸摄入量似乎是推荐摄入量，没有类二十烷酸生物合成或氧化受刺激的迹象。
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