Hoffman Lucas R, Kulasekara Hemantha D, Emerson Julia, Houston Laura S, Burns Jane L, Ramsey Bonnie W, Miller Samuel I
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.
J Cyst Fibros. 2009 Jan;8(1):66-70. doi: 10.1016/j.jcf.2008.09.006. Epub 2008 Oct 29.
Pseudomonas aeruginosa with mutations in the transcriptional regulator LasR chronically infect the airways of people with cystic fibrosis (CF), yet the prevalence and clinical implications of lasR mutant infection are unknown.
In an exploratory study, we screened 166 P. aeruginosa isolates from 58 CF patients for LasR inactivation and mucoidy, and compared clinical characteristics among source patients.
lasR mutation prevalence was comparable to that of mucoidy, the best-described CF-adapted phenotype, but affected patients were on average approximately 2 years younger. In a regression analysis, lung function decline with age was worse among patients with lasR mutant infection than in those without, similar to the effect of mucoidy.
Culture positivity for lasR mutant P. aeruginosa may serve as a marker of early CF adaptive change of prognostic significance. Furthermore, as LasR inactivation alters susceptibility to antibiotics, infection with lasR mutant P. aeruginosa may impact response to therapy.
转录调节因子LasR发生突变的铜绿假单胞菌会长期感染囊性纤维化（CF）患者的气道，但lasR突变体感染的患病率及临床意义尚不清楚。
在一项探索性研究中，我们对来自58例CF患者的166株铜绿假单胞菌分离株进行了LasR失活和黏液样变筛查，并比较了来源患者的临床特征。
lasR突变患病率与黏液样变（最具代表性的CF适应性表型）的患病率相当，但受影响患者的平均年龄约小2岁。在一项回归分析中，lasR突变体感染患者的肺功能随年龄下降的情况比未感染患者更严重，这与黏液样变的影响类似。
lasR突变型铜绿假单胞菌的培养阳性结果可能是具有预后意义的早期CF适应性变化的一个标志物。此外，由于LasR失活会改变对抗生素的敏感性，lasR突变型铜绿假单胞菌感染可能会影响治疗反应。
